The etiopathogenic theory of the gastroduodenal ulcer that is more in agreement with reality, is that of V. Bergmann, who has been verified by Ars in Anatomopathologic Studies.
Emotions, shocks, fatigue, nutritious disorders, etc., by means of the nervous-vegetative-endocrine system, determine a temporary ischemia of the mucosa, by vascular spasm or repeated local edema, which prevents the correct blood irrigation, and along with this, most of the time, spasms of the gastric musculature, that makes the irrigation more difficult. This is found in individuals predisposed by inheritance, manifested by hypersensitivity or deficiency of organic or mineral compounds. The excess of hydrochloric acid, with or without increase of pepsin, and the diminution or lack of protection of muco-protection of the mucosa are two more factors completing the picture to generate ulcers. But in the final analysis, to a general cause, the true etiopathogeny of gastroduodenal ulcers is outside the affected mucosa.
This is the reason why we can conclude that gastroduodenal ulcers are general diseases with local determinism; which implies that the treatments in vogue—and with greater reason the surgical ones—only correct a part of the etiopathogenic problem, leaving the ulcerous disease latent, so that in a certain time, the condition will return with all its signs and symptoms.
An etiopathogenic treatment would be one built on the greater number of causes, with which we would manage to carry out a true cure. By the results obtained in chronic patients, already treated with classic means, with complications where the neoformation of tissues are seen, it proves that until now this is the most rational of the treatments practiced, because it attacks all the causes known in special conditions that the etiopathogenic therapy makes more effective.
Clinical History Case # 1.
A.S.R., Female, Age 40, Weight 33kg (73lbs.), average fasting blood sugar 80mg.
Her father suffered of stomach ulcer, her mother of a hepatic abscess, she had two miscarriages, and a boy died at birth.
She has been constipated and has had, on several occasions, “intestinal infections.” She has been married for 16 years, without children.
Due to a painful abdominal syndrome, she was operated on 8 years ago by Dr. J. Castro Villagrana, discovering during the operation that the disorder was a duodenal ulcer. He performed a gastro-enteroanastomosis in July 1940. For some months there was a slight improvement, but soon the familiar sporadic mental symptoms, appeared with alarm. By the end of last year, the digestive disorder patient clearly presented a mental condition, and for this reason was taken to the USA. Dr. Leon Bader who examined her gave the following report: “Headaches, nausea, palpitations, abdominal pain, and diarrhea. For 10 years she had pain and vomiting after meals. After X-rays and examination, she was operated on for a duodenal ulcer performing gastro-enteroanastomosis. The vomiting and pain diminished in intensity and frequency, but then appeared diarrhea, abdominal cramps, and a loss of 15 pounds in a few months. Continuous pain in the epigastrium and the right quadrant, vomiting day and night, frequent occipital pains, hypertension the last 10 years, palpitations during the night that bother her much, with weak and irregular menstruation. Blood pressure is 230/110. Swollen an painful liver. On X-rays, the gastro-enteroanastomosis is clearly observed; the cæcum is observed to be very spasmodic. Red cells count 3,900,000, white cells count 7,100. Was treated with high doses of liver injections, vitamins, and folic acid; with the administration of Mesopin and Phenobarbital, she improved somewhat, though the diarrhea continued. This treatment lasted three months. In view of the fact that she worsened, they committed her to the Mount Sinai Hospital, having obtained improvement in her digestive symptoms, but worsening the mental ones. And for this reason they “passed her to the Bellevue Hospital where she remained nearly a month before returning to Mexico”.
On March 9th, of this year (1950) she displayed: delirium of persecution, auditory hallucinations, she constantly hears insults, does not eat anything because she thinks they want to poison her, has nausea and constant headache, laughs by herself, feels numbness in her feet and arms, does not sleep, does not answer any questions, and has total loss of memory. She has pain in the epigastric area, in the ascending and descending colon, and in the hepatic border. All the tendinous reflexes are increased. Blood pressure is 170/130, with edema in both extremities.
Painful syndrome similar to that of the duodenal ulcer that has produced a mental disorder of schizophrenia type, with a dysenteriform colitis and acute hepatitis.
- 20 Units of insulin intravenously;
- Calcium bromide 350mg,
- Magnesium bromide 250mg,
- Tartrobismuth of sodium and potassium 100mg,
At the second presentation of the Changes of the Blood Physico-Chemical Properties, she ingested bismuth and aluminum salts with 250mg of nicotinic acid.
After 20 treatments similar to the preceding, the patient has gained 6kg (13lbs.), without any mental symptoms, is just slightly constipated, eats all kinds of foods, and when she does so to excess, she feels some flatulence. Her weight before all her disorders was 42kg (92lbs.); it is now 48kg (106lbs.).
Clinical History Case # 2.
L.D.D., Male, Age 57, Weight 68kg (150lbs.), average fasting blood sugar 75mg.
The father died of a cardiac lesion; the mother of cancer of the larynx and she previously had a hysterectomy for uterine cancer. A sister died of sinus cancer.
He has neither alcoholism nor nicotinism, He has five healthy children, and has always had a moderate and clean life. He does not remember having had any serious disease that would have prevented him from attending to his occupations. He does not have luetic nor chemical antecedents.
On May 29th, 1943, this patient came to me, giving the following data: 14 years ago a slight pain started in the epigastric area 4 or 5 hours after meals. In the beginning, without radiation, it began with a sensation of emptiness and he made it disappear by ingesting more food or antacid. He had periods of three to six months without pain, alternating with two or three months of these symptoms. During this period, the symptoms were daily. In the last years the painful episodes were very intense with radiation towards the lumbar region “as if run through with a sword” according to the expression of the patient, which forced him to stay in bed. Coinciding with the exacerbation of the pain, the presence of a little mucous vomit, very sour, which defaced his teeth and calmed the pain. This was preceded by sialorrhea, and never was hematemesis, yet there was melena.
In August of 1940 the analysis of Mr. L.D.D.’s X-rays, requested by Dr. Felipe Aceves Zubieta says: “... Duodenal flexure: of little capacity; its repletion is irregular in both vertices; in the region of genu superior, pseudo-diverticular emissions are noticed. There is evidence of a niche in the base of the bulb. The passage by the bulb and duodenal flexure is done slowly.
Interpretation: Ulcer of the duodenal bulb. Respectfully, Andrés Villegas, MD.”
A few days before beginning with this treatment he was sent to take another X-ray whose results were: “Dr. Guido Torres Martinez, Londres 13, Mexico, D.F., June 8th., 1943. — Report of the radiological study of the stomach and duodenum of Mr. L.D.D. ... Duodenum: Duodenal bulb: constantly deformed, with a small niche in its base, by the inferior edge. — There is tenderness to the palpation at the site of the niche. — Slow duodenal transit.
Interpretation: small stomach, observed without abnormality. Duodenal Ulcer... G. Torres Martinez, MD.”
Clinically and radiologically this patient had a Duodenal Ulcer. Several times, he was subjected to periods of rest, diets, antacid medication, and injections of Histidine. While the medications lasted, he felt some improvement in some of his symptoms. Or on and off for a few months it seemed that they had all disappeared; but only while maintaining physical and intellectual rest.
About twenty days before accepting this new form of treatment, his condition worsened. He was sent to make the last radiological study whose results were given on June 8th.
On June 10th, 1943 he received the first treatment of Cellular Therapy. After 19 minutes he began to experience the Changes of the Blood Physico-Chemical Properties, showed by pallor, sleep, indifference, reduction of the pulse rate, etc. The pain, which before was very intense, clearly began to disappear. Within 30 minutes he had: abundant sweating and a state of semi-consciousness in addition to all the symptoms and signs already described. He then received the remedial medications following the technique previously described. Of the pain, only a slight feeling persisted. Since that time he could already eat all types of food with certain regularity. After the third application of Cellular Therapy, all the signs and symptoms of illness disappeared. By the time he had received 8 applications which were given irregularly, the patient had gained 20kg (44lbs.). He had started drinking alcoholic beverages in excess and he has not had the least concern in choosing his foods. Accordingly, he considered himself cured and abandoned this treatment before being discharged.
The medications provided in the first application were:
- 25 Units of Insulin intravenously;
- Calcium bromide 350mg,
and another syringe of the same capacity with:
- Tartrobismuthate of sodium and potassium 100mg,
At the second presentation of the Changes of the Blood Physico-Chemical Properties, the patient was administered 250mg of nicotinic acid, bismuth and aluminum salts in a sweetened drink.
From the third application of this curative treatment, in fact all the signs and symptoms disappeared. With great difficulties, in March of 1945, we were instrumental in obtaining from the IMSS (Instituto Mexicano del Seguro Social), the practice of a radiological study on him, whose result was: “... there are no apparent signs of ulceration, neither in the stomach nor in the duodenum...”
In the first days of February of this year he presented a painful syndrome with characteristics similar to those of his previous disease. For this reason, on February 24th, an energetic application of Cellular Therapy was performed on him, increasing the dose of the arsenical drugs, adding casein hydrolyzates and magnesium salts intravenously, and tryptophan intramuscularly.
Dramatically, all the symptoms disappeared in one hour, and as of that date he has returned to his normal life. In the Hospital of Nutrition they did the clinical and radiological studies on him whose results we transcribed: “April 12th, 1948... in this study the existence of a niche is not observed. J. Deschamps, M.D.” “May 6th, 1948. Radiological Impression: NORMAL stomach and duodenum. J.M. Falomir, M.D.” “August 6th, 1948. Radiological Impression: Very discrete hypertrophy of the folds of the duodenal mucosa, with practically no deformation.— J.M. Falomir, M.D.” Dr. Horacio Jinich made the clinical study and the patient was discharged because of the finding of healed duodenal ulcers.
Clinical History Case # 3.
F.R., Male, Age 57, Weight 54kg (119lbs.), average fasting blood sugar 80mg.
As a boy he had a tapeworm of 11 meters, and several times he suffered from dysentery.
Over five years ago, it began with a sensation of “like air in the stomach.” Later, and without apparent cause, in the same spot he felt pain that sometimes only improved when eating. Sometimes it also caused him nausea and vomiting of yellow-greenish matters. The various treatments did not improve it. The first X-ray studies did not show any gastric or duodenal disorders: “...we observe deformity of the first portion of the duodenum, with filling defects. (This can be due to periduodenal adhesions). L. Deschamps, M.D.” At the present time he has very good appetite, in addition to the pain and vomiting, very hot belches that burn the whole digestive passage, much flatulence increasing after meals, very constipated, migraine more on the right side, and frequently rheumatic pains in various parts of the body, palpitations that sometimes keep him from sleeping, general asthenia, frequent nasal discharge accompanied by dry cough and dyspnea.
During 5 years he has been put under the various therapies in vogue; but in spite of them all the symptoms have increased alarmingly.
In the different stool examinations no parasites were found, and his luetic reactions have always been negative.
The examination reveals: larger right pupil, very coated tongue, intense pain caused by palpation in the whole epigastric region. Pain at the vesicular point, which increases with deep inspirations, percussion of the liver feels large and painful. The spleen area sounds dull to percussion, in proportion larger than normal.
There are whistling stertors at the base of both lungs, more on the right side, and dull to percussion.
Blood pressure: 120/70.
Radiologically and clinically it is a case of duodenal ulcer with adhesions by periduodenitis with chronic bronchitis, that has produced chronic hepatitis.
The Cellular Therapy treatment began in November of 1947. As in all these cases, all the symptoms began to disappear as of the first treatment. There were 20 treatments, one per week, before his discharge with complete cure. He now lives as before his disease, with all his activities and eating all kinds of foods.
Like all the gastric or duodenal ulcer patients, half an hour after the application of the pancreatic hormone, he displayed the signs and evident symptoms of the Change of the Blood Properties and at the 33 minute mark, in view of their intensity, he received:
of sodium arsenobenzene 10g,
- Calcium gluconate, 120mg,
and another syringe of the same capacity, with
- Tartrobismuth of sodium and potassium 100mg,
At the return of the Change of the Blood Properties, he received bismuth and aluminum salts with nicotinic acid 250mg, in sweetened water.
There was no variation in the dose of medications. From the beginning the dose of insulin was 25 units intravenously. The average of time in which the patient began to feel the Change of the Physico-Chemical Properties was at 27 minutes in the first treatments and 34 minutes when the Change was complete. This is to say, the Therapeutic Moment. The later average was 31 minutes for the beginning and 46 for the complete Change.
When we are dealing with patients where there are no complications, it has been observed that as the ulcerous symptoms are improving, they become less sensitive to the action of the pancreatic hormone. In these patients, the variations in time can be easily observed.
The hormone of the pancreas produces a series of changes in the blood bio-physico-chemical properties and surely in the core of each cell, which changes its general metabolism, and taking advantage of this movement, probably all the cellular components are modified, and undergo a new arrangement later, as we demonstrate in another chapter.
A deep endocrine dysfunction favoring the inhibition or the excitation of certain hormonal functions takes place.
As the humoral environment is modified by the change of the blood pH, there is change in digestive secretions and change in all the dyscrasic phenomena.
The patients with gastritis, ulcers, and gastroduodenal cancers, are extremely sensible to the effect of insulin. We can insure that in this manner any diagnosis is checked until being exact. All are insulin sensitive.
Many mental patients have gastroduodenal disorders as prodromic symptoms.
Extending the field of application of insulin, we must say that it is in the gastroduodenal disorders where it demonstrates its superiority to the dedicated medical treatments and all surgical procedures; not as basic treatment but only to take advantage of the bio-physico-chemical blood changes it produces.
Other medicamentous adjuncts to the gastroduodenal therapy in use, are: the trivalent arsenic and hydrolyzed proteins.
All the patients treated with this system have been previously subjected to all the well-known therapies. We have obtained to date nearly one hundred percent success, which means that they would all be cured if, as soon as the diagnosis is made, the Cellular Therapy was applied to them.
In all or almost all cases, the pain disappears immediately.
None of the patients cured with this system are subjected to any diets or special regime.
Within the following twenty-four hours, there is migraine, mild fever, and general asthenia. These are the present maximum symptoms and in no case is the life of the patient is in danger.
From 1943 to 1953, 38 patients with well diagnosed gastroduodenal ulcers have been treated with Cellular Therapy.
Surely it is not the treponemicidal action of arsenic that works on ulcers. We must explain its good results by the following facts: The congestive action is immediate to its application, especially when it is intravenous. This effect is very clearly seen in the nitritoid crises. The first and foremost symptoms are always congestive and in a great number of cases, the patient refers to the stomach, because the malaise sensation is epigastric. This is verified by the vomiting that sometimes alleviates or compounds the disorder.
Sir James Sayoyer found its use advantageous in gastralgias produced by hyperchlorhydia. The old therapists used arsenic in all classes of anemia, apparently with very good results; now it is the turn of liver and folic acid. Arsenic increased the nutrition and prevented the demineralization of the organism. It is still being used as such, without being the favorite medication.
One of the first ulcer patients in which we began to use arsenic was also syphilitic, and for this reason we tried to find the chemical combinations that at the same time cured both ailments. From here its systematic use began in the ulcerous disorders in which the patient did not have any antecedent of syphilis. In all the cases in which we have used arsenic, the signs and symptoms disappeared clearly and quickly. When we tried to eliminate arsenic to verify if in fact it had beneficial action in the treatment of ulcers, the results were not as satisfactory. This is why we now can affirm that it is one of the basic medications in the treatment of the gastroduodenal ulcer. We performed a last and definitive experiment on one patient. After his receiving Cellular Therapy and being apparently cured of a duodenal ulcer, he remained for some years without problems, committing all sort of improprieties. One day his symptoms began with an intense peculiar pain, already known to him, the same as the one of the duodenal ulcer. We studied his clinical history, anticipating that he was going to experience high fever. Arsenic was the only medication that was different. The beneficial result was instantaneous, in his very bed before ever getting up, all the symptoms disappeared. A few days later he was examined in the Hospital of Nutrition, and the radiological and clinical conclusions were that the duodenum ulcers were completely healed. See clinical history case # 2. If it were not for the proper disorders produced by the arsenical drugs, the treatment with high doses of this medication would be almost instantaneous. We find its use well justified in all types of gastroduodenal ulcers.
Eatschow calls our attention to the beneficial results of Estrone that is regularly injected intramuscularly, beginning with one milligram and going up to five, evaluating the susceptibility of the patient every third day.
Also the male sexual hormone now finds much application in ulcer treatments, because some authors maintain that it improves the peripheral as well as the internal organ circulation, since it suppresses arteriole and capillary spasms.
Weiss and Aron attribute gastroduodenal ulcerous lesions to a deficiency of amino acids. This appeared in experimentation on one hundred percent of the dogs between the duodenum and the ileum’s end. Tryptophan and Histidine injections have prevented the evolution or the occurrence of ulcers. However, all the dogs in the experiment died without exception, for the lack of these amino acids whose action is the increase of the gastric mucosa, which produces the insertion of these substances. In addition, Tryptophan and Histidine accelerate the healing of any lesions. We attribute a general sedative action to both amino acids, perhaps by the hyperproduction of the mucosa. They are vasodilators, which indirectly prevent spasms, and are materially specific for cellular repair.
The achieved therapeutic success with the administration of amino acids does not always mean that the organism suffers a lack or a deficiency of these. It can be that they only increase the nitrogen elements in general; allowing therefore the synthesis of other amino acids, which are, in this pathologic moment, necessary to the organism.
The hemoglobin constituents hematin and globin lock up in their structure a tetrapyrrolic group and imidazole (glyoxaline). As the nuclei pyrrole and imidazole are not synthetizable by the organism, and respectively are part of Tryptophan and Histidine, with these amino acids, remarkable increases of hemoglobin and red cells have been obtained. This is the reason why the therapeutic indications are found where there is blood deficiency, as occurs in ulcerous patients.
Many ulcerous patients must be injected with the ten amino acids called essential; this must be done when there is no clear response to Histidine and Tryptophan.
Another one of these helping medicines is ascorbic acid that works in concert with other vitamins and it is applied intravenously.
PYLORIC STENOSIS CURED WITHOUT SURGICAL INTERVENTION
Now that surgery has reached its greatest splendor, we presented these works on the treatment of PYLORIC STENOSES, which have always been treated surgically, due to their mechanical nature. Merely to think that there is another way to solve them, that is not surgical, seems an aberration. But the facts that we are going to present demonstrate that the medical treatment we call Cellular Therapy has greater advantages, because: there is no danger of surgical shock, there is no danger of postoperative complications, there is no special diet, nor the special care that these patients must always follow for the rest of their lives. The observations that we have gathered during more than 6 years on the most serious patients, force us to think that this is how it must occur in most of the cases treated with this system.
The Stenosis takes place by obstruction in the lumen of the pylorus, the walls or their contours: A foreign body, a pediculated growth, in the lumen of the pylorus; the lesions of the wall, normal or of cancerous origin; and most frequent: those caused by duodenal, prepyloric, juxtapyloric, and duodenopyloric ulcers.
We will not speak of those coming from extrinsic causes.
Pyloric Stenoses, almost always a consequence of an ulcerous or neoplastic process of the duodenum, are the most frequent and they are those we are going to refer to.
The lumen of the canal can be obstructed from 1 to 10cm; it is always eccentric and it will allow a certain amount of liquid to pass. When the obstruction begins, the gastric muscle exaggerates its peristalsis, and soon fatigues. Finally atony comes, chyle is accumulated at the gastric bottom, and the walls of the stomach are distended, arriving sometimes at enormous dimensions.
Radiologically, gastric ptosis is different from expansion by stenosis, because in the first, the stomach takes an almost spherical form, its vertical diameter is greater than the transverse; however in stenosis, the shape is of a half moon and the transverse diameter is greater than the vertical. The peristaltic movements are almost nonexistent, and as the stenosis progresses they decrease until being null.
First, let us mention the X-ray study that always makes or clarifies the diagnosis.
The symptom that generally opens the scene is the sensation of gastric tension that the patient experiences. This increases for up to two or three hours after taking food. It quickly turns into a painful cramp, that is almost always mitigated by the ingestion of some food or antacid. The nausea continues, and finally vomitus: first of sour liquid, and finally comes the food appearing between 4 and 7 hours after being ingested. This vomitus produces a great relief to the patient. As a consequence, a rebellious constipation alternating with false diarrhea, is common. When this local condition is reached, the general condition has been greatly affected: general asthenia, deep pallor, and emaciation.
With Pyloric Stenosis having been discussed clinically and radiologically, we are immediately going to talk about some cases treated with Cellular Therapy.
All the patients treated are ambulatory, and therefore their control has been very difficult. For this reason we are going to present a few that have been studied perfectly.
Clinical History, Case # 1.
CM, Male, Age 66, Weight 56kg (123lbs.), average fasting blood sugar 90mg; occupation: farmer. May 1944.
He does not have any personal or pathological antecedents of importance.
For more than 30 years he has been having undefined digestive disorders. In the last 20 years he has consulted many doctors. In spite of medications used for his ailments, in the last 5 years, the major symptoms have been: intense pain in the mouth of the stomach that for more than 1 year has been accompanied by vomit coming one hour after having ingested foods. In the beginning, they were water brashes, and lately they consist of food. Sometimes they are nocturnal, preceded by pain. Those disappear when vomiting the foods that he took during the day. Sometimes the vomit is fetid of odor and taste. Lately, the pains have been more intense, and he has had sensations of stretching, cramping, or of tearing. This improves in the beginning, with the exit, by the mouth, of the gastric contents. The vomiting has been incoercible, not responding to any of the indicated medications. The pain is continuous, and it has barely been letting him sleep one hour daily, for 7 months. He has not evacuated the intestine for periods of up to 15 days. Normally, every 8 days some evacuation is obtained with an enema.
The emaciation is obvious. He has lost 20kg (44lbs.)in these last 7 months. The asthenia is deep, the general aspect is one of a seriously ill patient.
Examination shows a very irregular shape of the abdomen. The portion that is above the navel is very dilated and convex. The part that is below looks like a trough. The superior part is painful to palpation, with muscular guarding. On both sides, the colon is felt perfectly. The abdomen is extremely distended in the upper part, and faint in the lower part. With the examination maneuvers, the eyes are more receding, the outlines of the face are more drawn, and the nose is sharper. In short, the face is clearly peritoneal.
The breathing is superficial and accelerated, 25 breaths and 106 pulses per minute; blood pressure 125/70.
The X-ray study says: “... hard gastric expansion mainly at the level of the antrum, with pronounced extension of the stomach. The transverse diameter of the stomach is much greater than the vertical. Abundant liquid in fasting. The X-ray taken in standing position shows deformations of the minor curvature that are not persistent. At the eighth hour mark, almost all the barium is still in the stomach, a small amount having passed into the intestine... Radiologic evaluation: ADVANCED PYLORIC STENOSIS. The cause of this stenosis is not perceived radiologically, it could be of ulcerous, neoplastic origin, etc... Jose Ramirez Ulloa, M.D.” See X-rays.
The intense gastric expansion, with predominance of the transversal diameter over the vertical, the permanence of the barium for more than eight hours, the small amount of barium that passed into the intestine, are radiological data conclusive to diagnose ADVANCED PYLORIC STENOSIS, corroborating the clinical diagnosis.
Every five days, he received the application of this curative medical system called Cellular Therapy. From the third application there was a sharp improvement. At the fourth, the vomiting disappeared. The pain decreased much and the intestines began to evacuate. This improvement allowed the treatment to be applied every 8 days. He received altogether 7 applications. All his digestive functions were normalized, feeling healthy and having gained 10kg (22lbs.) in two months. That was the end of the treatment. Without having received a discharge and therefore without previous examination, he quit the treatment.
Four and a half years later, he came back, and to corroborate his state of health from which he was boasting, the X-ray study with the following result was made; “Mr. C.M.... The strong gastric expansion has disappeared, mainly at the level of the antrum... Now the air chamber is normal. The liquid in fasting is little. The deformations of the smaller curvature have disappeared... A duodenal diverticula persistent in all the X-rays is observed... Some gastric spasms near the duodenal bulb... The barium passes the duodenum well, which has allowed the observation of the diverticula. Jose Ramirez Ulloa, M.D.” See X-rays.
Clinically and radiologically, the patient had Advanced Pyloric Stenosis caused by a duodenal ulcer. Four years after having received an incomplete treatment of Cellular Therapy, it was verified that the Advanced Pyloric Stenosis had disappeared, clinically and radiologically.
Clinical History, Case # 2.
A.V., Male, Age 35, Weight 62kg (136lbs.), average fasting blood sugar 78mg, employed; was examined on June 4th, 1946.
He had tertiary malaria for two months; gonorrhea and syphilitic chancres, the luetic reactions having always been positive in the blood. During 5 continuous years he has been treating his lues (syphilis) intensely and methodically, although, in March of this year, the Kahn test in the Cerebrospinal Fluid was positive with a slight increase of albumin.
Since before the blood positive feedback, meaning for more than 5 years, ingesting certain foods caused him intense pain in the stomach. This could disappear with some antacids. In the last months this has changed. The pain is more intense before meals, and food makes it disappear, which has motivated him to eat food at any time to mitigate the pain. But now it has become constant.
For 22 days, not even the ingestion of food has given him relief. The pain has generalized in the whole abdomen. Standing upright also increases the pain. His abdomen has always been distended with gas; it now increases when he eats. Gas expulsion alleviates it, but its release causes intense rectal pain. In one month he has lost 11kg (24lbs.), and his strength.
Examination shows that the abdomen is enlarged by gases. Pain is generalized with palpation. There is muscular guarding. The liver is painful, and the edges are felt. The splenic area is large and painful. Blood pressure is 110/65.
The X-ray study says: “... in the pyloric region there is a very remarkable deformation, caused by repletion, which also includes the duodenal bulb and the first portion of the duodenum. The X-ray image of the bulb is limited by a THIN LINE that corresponds to the small curvature of the organ. The rest of the picture having disappeared, this line presents, in its lower edge, a recessed form, giving a paracyclic aspect. The first portion of the duodenum appears in irregular shape of scalloped or scattered edges. There is pain to manual pressure applied to this region... STENOTIC duodenal ulcer with carcinomatous process of the pyloric region of the stomach, duodenal bulb, and first portion of the duodenum... Manuel Herrera Sobreyra, MD.” See X-rays of AV.
The progressive and rapid clinical advance, and the radiological data show us that we are dealing with PYLORIC STENOSIS, caused by a carcinomatous process of the duodenum, in syphilitic terrain.
According to the norm established in this therapy, he received intravenously 30 Units of insulin; 35 minutes later, the hypoglycemic symptoms began, but they disappeared after a few minutes. One hour later, he received 25 more Units, without obtaining the desired symptoms. Again, 45 minutes later, 20 Units additional were applied to him. Twenty minutes after the third injection all the clear symptoms of the Change of the Blood Properties began, and within 28 minutes they had reached their maximum, that is the Therapeutic Moment being sought. He received intravenously:
of sodium arsenobenzene 10g,
- Calcium gluconate 1g,
- Magnesium bromide 500mg,
- Tartrobismuth of sodium and potassium 100mg,
At the second presentation of the symptoms of the Change of the Blood Physico-Chemical Properties, bismuth and aluminum salts with 250mg of nicotinic acid, in sweetened water were given.
He received the treatment every 5 days, and from the first three he clearly began to feel better. After the third, he received it every 8 days; but the irregular effect observed from the first application got stabilized at the sixth treatment. During the last three, he was injected with 90 Units of insulin intravenously. The average time to begin the symptoms was 40 minutes, and 73 minutes when these reached their maximum intensity. There were a total of 10 applications. He felt completely cured because he ingested all types of food without the smallest problem. And without the X-ray or clinical control, he quit the treatment.
On April 26th, 1948, that is 2 years later, Mr. A.V. came back. He appeared to be in perfect health. He only came to thank me for his feeling perfectly healthy. We requested that he get some X-rays taken. He promised to do it; this one — like all ambulatory patients as soon as they improve — abandoned all types of treatment. In October of 1948, two and a half years later, he sent us a letter, from which we have selected the following paragraphs: “...You saved my life, because the opinion of several doctors of different districts decided that an immediate operation was necessary... In the state in which I appeared to you, I weighed only 62kg (136lbs.), my normal weight being 84kg (185lbs.). Each one of the series of 6 X-rays showed a duodenal ulcer... With the first treatment that I received I felt better and so on my health was improving, and when I had been treated 10 times I was already completely well, and weighed the same, until getting to weigh 92kg (202lbs.)... A.V.”
The complete elimination of all the digestive disorders, the remarkable increase in weight, and the return to normal activity of the subject, after more than two and a half years, forces us to think that the pyloric communication had been restored, in such manner that it is possible to have given his health back to this patient, without the mandatory operation, in these conditions.
Clinical History, Case # 3.
F.P.G., Male, Age 56, Weight 55kg (121lbs.), average fasting blood sugar 70mg, military man, December 1944.
His father died of an intestinal disorder. His mother of an indefinite gastric disorder. His wife had two miscarriages and two healthy living children.
During many years he drank great quantities of alcoholic beverages; he has clear antecedents of contracted syphilis, which have been treated intensely, until the reactions came back negative and all the symptoms had disappeared.
In February of 1942, he had peritonitis, caused by acute appendicitis, which was treated and cured by Cellular Therapy. He recovered the 12kg (26lbs.) he had lost. In order to verify his state after this treatment, a laparatomy was performed, finding a floating appendix, without any macroscopic lesions.
In December 1943, inopportunely, he felt an intense pain in the epigastric area, with nausea and general distress, which did not yield to any medications. His discomfort increasing, he appeared at the Central Military Hospital; Dr. Mario Quiñones made the clinical study and Dr. C. Gómez del Campo, the radiological study. The conclusions of both were: “DUODENAL ULCER WITH STENOSIS, requires immediate operation...”
Apparently, without dyspeptic antecedents, appeared intense epigastric pain with nausea, followed by a month of vomiting, first sour, later watery. The burning became worse after meals, which came back about 5 hours after having taken food, still with malodorous regurgitation of food. For nearly two months he was put under tranquilizers that did not alleviate the pain. Loss of strength and general emaciation were the result of these two months of his acute state.
Examination showed peritoneal facies, with an individual very emaciated and pale, clearly denoting pain. His abdomen was very distended with gas, with muscular guarding, or simply abdominal tension. Palpation brought on peristaltic movements that produced pain, followed by gas expulsion, with which the patient obtained some relief.
During the examination maneuver, the patient had vomits of butyric odor.
On March 11th, 1944, he received the first application of Cellular Therapy, with the following medications:
-30 Units of insulin, intravenously;
of sodium arsenobenzene 10g,
- Calcium bromide 350mg,
another syringe of 20cc, containing:
- Hydrochlorate of histidine 200mg,
At the second presentation of the symptoms of the Change of the Blood Physico-Chemical Properties, aluminum and bismuth salts with 250mg of nicotinic acid in sweetened water were given.
From the first application all the symptoms clearly began to disappear, in such manner that only two treatments were sufficient to leave him for more than two months without any medications; after which they were started again until 10 treatments were completed.
On August 18th of the same year, Dr. J. Ramírez Ulloa said in his radiological report: “...Stomach: Fills like those of orthotonic type. Normal air chamber. No liquid is observed in fasting state. Shape, volume, and situation normal, without deformations of the contour or accidents of the curvatures. There is expansion of the pyloric antrum that INDICATES STENOSIS PROCESS. Duodenum... no shades of ulcerous niches are observed... August 18th, 1945. J. Ramírez Ulloa, M.D.”
To date, he carries out all his activities efficiently and he does not have any nutritional regimen; he enjoys perfect health.
Clinical History No. 4.
J.P.P., Male, Age 47, Weight 59kg (130lbs.), average fasting blood sugar 80mg. September 29th, 1950.
He had amebic dysentery, Malta fever, and digestive disorders all his life. He has been deaf in the right ear from childhood.
A year and a half ago the indefinite digestive disorders increased, with constant symptoms, and more annoying has been the sensation of “flatulence” of all the abdomen, which increased after meals. It seems that his esophagus was burning and for nearly 2 months he has been vomiting. In the last 15 days he vomits everything and the food he ingests does not stay in the stomach. This is the reason why he has lost 14kg (31lbs.) in such a short period.
Examination shows distressed facies, a palpable large liver within its borders, painful right colic cord. Blood Pressure of 110/85.
The X-ray study conducted by Dr. Emma Rosa Coraminos Gálvez says: “...Stomach very large, hypotonic, with its very low bottom in bucket shape. There is pain to pressure in the site of the duodenal bulb that only fills up by manual pressure. Peristalsis is clearly diminished, but it exists, and IT MANAGES TO PASS A LITTLE THROUGH THE PYLORUS. In the other X-rays it was not possible to find an even slightly impregnated duodenal bulb... Radiologically: Gastric Atony. PYLORIC STENOSIS caused by a possible duodenal ulcer. Emma Rosa Coraminos Gálvez, M.D. September 12th, 1950.”
The clinical data are not enough to make the diagnosis of PYLORIC STENOSIS; but all those given by the radiological study are quite clear, as it is possible to observe in the attached X-rays.
On September 29th, he received the first application. Two days later he began to take liquid foods that he no longer vomited. On the third day solid food was taken that he did not vomit, either. On the seventh day he received the second treatment, and seven days later the third, interrupting when it was time for the fourth because the patient believed he was already cured. He then ate to excess in quantity and quality, and after 15 days he vomited three times, which alarmed him, and made him resume the treatments on November 3rd.
He received two more applications and the improvement continued. We hoped that when finishing without interruptions a series of ten, we would do the X-ray studies to give him a discharge or to continue his treatment.
Clinical History Case # 5.
E.D.M., Female, Age 38, Weight 60kg (132lbs.), average fasting blood sugar 80mg, country school teacher. Was examined on October 4th, 1950.
A brother died of duodenal ulcer.
Without apparent cause in 1941, all of a sudden she felt an intense stomach ache, which lasted two days. With a few injections, it disappeared and everything returned to its previous state.
In August 1945, at midnight, and also without apparent cause, she began vomiting with epigastric pain. At daybreak, she took a laxative of castor oil and was a few months without discomfort.
In 1948 the vomiting was accompanied by extreme pain under the ribs near the liver region. The diagnosis of clinical Cholelithiasis was made. During 3 months she was put on milk, eggs, and medications for ulcer. But she vomited everything and it produced intense pain, for which they gave her daily 6 ampoules of Sedol, the last days of this regime, and changed the whole nutritional regimen for corn flour drinks without milk and gelatin, with which she got some improvement. They took some X-rays which showed that there was no ulcer. Then in June of 1948, she was operated on, finding the gall bladder all right; only there was a “cyst” that obstructed the lumen of the biliary duct. Again she started to have eggs and milk, tolerating them well, for about a year. By the end of 1949, the vomiting and the pain returned, without reasons attributed to them. X-rays were taken of the stomach and duodenum, and found the latter healed. In spite of this, she was getting worse, and by the end of September and beginning of October, during a month, the pain was the same. Day and night she was vomiting everything she was putting in her stomach. In fact, for nearly a month, she was without any food. Fifteen minutes after ingesting liquids or solids, they were thrown up by the mouth. The constipation had been accentuated. She had lost 20kg (44lbs.) during this time.
A continuous Ouch! was the greeting of this patient. She had sunken eyes, a very pale, suffering face. Above the navel there was muscular guarding. Slight contact with the hand increased her pain. For this reason we could not do an examination of the abdomen. Blood Pressure at 120/80.
The X-ray study says: “Dr. Jorge Segura Millán... Small air chamber. Slight amount of stasis liquid in fasting, normal esophagic transit... stomach very incurvated on itself and with prepyloric portion dilated. In the small curvature, picture in persistent screen is observed during the initial phase of gastric contractility; initiated in their greatest intensity, the contractions disappear from the previous picture. Contractions of initiation and normal form, with frequency and intensity very increased, are observed, gastric segmentation by the intensity of same, but the evacuating is not in relation because of PYLORIC OBSTACLE. Later, small superior bulb, badly inflated with undefined edges, painful... The evacuating is slowed down and in the final stages, the intensity of the contractility decreases and there is a slight expansion, mainly antral... Duodenal bulbar uncus in front with microbulb by retraction and periduodenitis, the preceding indicated INCOMPLETE STENOSIS of pylorus with initial hyperperistaltic antral dilatation and following hypotonia with relaxation and gastric stasis... Jorge Segura Milan, M.D.”
On October 4th, the first treatment of Cellular Therapy was applied to her, almost obtaining the disappearance of the pain and the renewal of intestinal evacuations, until the fifth treatment when the vomiting disappeared, and she began to eat meats, milk, juice, etc.
After 15 treatments she was discharged, insisting that she take some X-rays to know the state of her disease. She left the capital, and returned to her work, and in one of her letters she said: “... When I came to you, I had been suffering for more than two years from very strong colics due to the ulcer that I had in the stomach, which caused the total closing of the duodenum. ... at this time I am eating all kinds of foods without causing me any discomfort, although before your treatments I had been on a rigorous diet for more than two years.
This letter is intended to inform you about the health condition of your patient. E.D.M.”
We presented five clinical histories where the radiological as well as the clinical study demonstrate to us that we are dealing with PYLORIC STENOSIS. The first and the last three caused by duodenal ulcers and the second by carcinoma of the duodenum; another one in the process of healing.
The stenosing cases by neoplasmas have therapeutic variants as was observed in the case that we presented.
After six years of observation, the patients remained in a perfect state of health. One has more than 6 years, and two others, more than seven.
In these STENOSIS cases, no surgical intervention was necessary.
The time of treatment used in Cellular Therapy was not greater than 3 months, without interrupting the patients’ habitual customs.
We have registered more than 50 clinical and radiological cases of this disease; but as they were not hospitalized, it has not been possible to gather any subsequent data; we only know that they have been healthy.
Before, during, and after this treatment, there is no danger for the life of the patient or for any of his organs. If the diagnosis is incorrect, the application of this therapy is never offensive, when following all the guidelines of the technique already established.
I. — As it is demonstrated in this work, there are other inoffensive procedures—not surgical—to treat PYLORIC STENOSIS, that must be tried by doctors specialized in these diseases so that they may contribute with their observations.
a. — Systematically, as soon as the correct STENOSIS diagnosis is made, this treatment must be applied; and if it fails, go to the operation as a last resort.
b. — The observation of these patients must continue later to assure the efficiency of the treatment. Even if this treatment has been temporary, whenever the patient returns with symptoms or such similarities, this curative system can be reapplied.
II. — Because the true etiopathogeny of PYLORIC STENOSES is outside the affected mucosa, and BEING GENERAL DISEASES WITH LOCAL DETERMINISM, all the treatments in vogue, medical or surgical, are only temporarily palliative.
III. — For the present we can say that, since this treatment has worked on the majority of the cases, it must be considered as truly ETIOPATHOGENIC and therefore the most rational for the treatment of PYLORIC STENOSIS.
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