IPT AND THE TREATMENT OF HIV INFECTION: Clinical experience to date.
Published on IPTQ with permission from Donato Perez Garcia, M.D.
[ I believe this article was distributed as part of a poster presentation at an AIDS conference. ]
The two following cases represent our own pilot study to investigate the
efficacy of IPT in the treatment of AIDS/ARC. Starting with the new cases that
will be coming under treatment in Nexcio this month, we intend to standardize
the gathering of clinical and laboratory information, so that this may be
reported in a more organized fashion. Plans. have been made to have sera from
all patients sent to Ortho Diagnostics of Newark, New Jersey, on a regular
basis. Ortho will be performing initial immunologic evaluations as well as
frequent follow-up determinations on all these patients. A periodic reporting on
this clinical experience will be sent out to a number of investigators in the
field of AIDS research.
This is the case of a 47 year old homosexual male with a diagnosis of
AIDS-related-complex (ARC). The diagnosis had been established on the basis of
clinical findings, two successive positive HTLV-III antibody determinations and
a positive Western Blot assay for HTLV-Ill antibody. The serologic diagnosis was
confirmed by the Centers for Disease Control in Atlanta. Having been apprised of
the poor prognosis for his disease, this patient elected to undergo treatments
with IPT. When he presented for consultation on November 25, 1986, the patient
had complaints of a recurrent herpes zoster infection on the left side of his
head and neck, painful cervical, axillary, and inguinal lyrnphadenopathy,
fevers, malaise, weakness, diarrhea, headache, irritability, poor memory,
depression and a weight loss of 15 kg (30 lbs) over the last 6-8 weeks. On
physical examination, his BP was 140/60, temperature 370 C, weight 72 kg. Head
and Neck: On the left side of the neck and over the left retroauricular area,
there was a polymorphous dermatosis consisting of erythematous plaques with
vessicles, pustules, nodules and crusts. On' both sides of the neck there was a
chain-like mass of nodes the largest of which measured approximately 2 cm. in
diameter. These nodes produéed a visible distortion on the sides of the neck,
they were tender to palpation, and they caused a restriction of lateral movement
in the neck. The rest of the examination of the head and neck was unremarkable.
The patient began a series of IPT treatments on' November 27, and received
these following medications:** Regular insulin 6u/IY. Oral:
Coincident with the patients undergoing these treatments, his clinical
situation became much improved. His diarrkea lessened greatly following the
first treatment. By the third it had disappeared completely, as had the fevers,
headaches, poor memory and depression. The patient reports feeling well in all
repects, and has resumed his normal
This is the case of a 22 year old Mexican homosexual male who was found to be HIV positive and developed signs of encephalopathy with severe, debilitating dementia. The patient underwent IPT treatments for 4 months in Mexico City. During this course of treatment, all signs of the patient's presumed intra-CNS HIV infection resolved completely with a full return of normal function, physical and mental. It is reported that two follow-up HIV antibody tests (Elisa) were performed in Mexico City, and that these tests were negative on both occasions. No other testing has been done. Because of the full recovery from his clinical situation, this patient feels that continuing treatment and testing is unnecessary, and, as of June 1, 1987, he has been lost to further follow-up.