(from Clinical Experience with the Practice of Insulin
Potentiation Therapy: Best Case Series by Donato Perez Garcia y Bellon, M.D.,
Donato Perez Garcia, Jr., M.D., and SGA, M.D. Presented at Monitoring and Evaluation Approaches
for Integrated Complementary and Alternative Medicine Cancer Practices, Bethesda
Hyatt Regency, Bethesda, MD., USA. August 4 - 6, 1997.)
Adenocarcinoma of the Pancreas, a case history
This is the case of a sixty-four year old
female who developed scleral icterus in September of 1986. This was followed by the
appearance of jaundice and symptoms of nausea and anorexia. In October the patient sought
consultation with her physician about these complaints, and an ultrasound examination of
the liver and bile ducts was done on October 22. This reported a normal liver parenchyma
without evidence of metastasis, the presence of cholelithiasis, and dilatation of the
intra and extrahepatic bile ducts due to extrahepatic obstructive jaundice. The
differential diagnosis was cancer of the head of the pancreas versus cancer of the ampulla
of Vater (figure VII.1). On October 27 a CAT scan of the abdomen was done,
confirming suspicions of a pancreatic cancer (figure VII.2). The patient was
apprised of the possible diagnosis and the poor prognosis under her circumstances.
In December, the patient went to the M.D.
Anderson Cancer Center in Houston,Texas, to be treated for her condition. There she had a
choledochoduodenostomy performed. During the intraoperative period a needle biopsy was
taken from tissue in the head of the pancreas, and this reported an adenocarcinoma (figure
VII.3). Apart from this palliative surgical procedure (choledochoduodenostomy), the
patient received no other form of treatment for the management of her disease.
In January, 1987, the patient presented to the Drs. Perez Garcia for treatment of her
condition with IPT.
- PHYSICAL EXAMINATION: The patient is a
sixty-four year old female complaining of a three months history of nausea, anorexia,
scleral icterus and jaundice, and a weight loss of 12 kg (27 lbs). She states that her
jaundice has diminished somewhat since her surgery in December, 1986.
Height: 5 feet 3 inches (1.6 m). Weight: 104 lbs (45.9 kg).
Blood pressure: 190/130 mm Hg. Pulse: 90/ min. and regular.
Temperature: 37.3º C. Respirations: 18/min.
Head & Neck: There was some slight residual scleral icterus, otherwise the
HEENT were normal.
Chest: Several supraclavicular lymph nodes are palpable on the left and these are
slightly tender. The lung fields are clear. The second heart sound is augmented in
intensity, otherwise the heart sounds are normal without murmurs or extra sounds. The
heart rate and rhythm are normal.
Abdomen: Soft and scaphoid. No liver, spleen, or kidneys are palpable. There is a
firm, tender mass palpable in the epigastrium. The bowel sounds are normal.
Central nervous system: Grossly normal.
On January 15, 1987, the patient began a
series of IPT treatments. The medications administered included: regular insulin 12 units
IV; Genoxal (Schering - cyclophosphamide 500 mg/25 ml) 0.5 ml IM; Methotrexate (Lederle -
methotrexate 50 mg/20 ml) 0.4 ml IV; and Fluorouracil (Roche - 5-fluorouracil 500 mg/10
ml) 0.2 ml IV. The patient underwent a total of eighteen treatments which she tolerated
without adverse effects - either from the chemotherapeutic agents or the insulin.
Clinically, her condition improved with this therapy. All her gastrointestinal symptoms
abated and she was able to regain her lost weight. Her abdominal exam became essentially
normal, and the supraclavicular lymphadenopathy and scleral icterus likewise cleared.
On April 22, 1987, an ultrasound examination
of the liver and bile ducts was done which reported a tumor in the head of the pancreas
measuring 32 x 30 mm (figure VII.4). A repeat examination done on June 5 reported
the body and tail of the pancreas to be normal in size with areas present in the head of
the pancreas compatible with tissue necrosis (figure VII.5). Following the
ultrasound examination in June, the patient began to take treatments on a once-a-month
basis instead of once weekly. After her last treatment on October 2, 1987, this patient
was lost to further follow-up. At that time, she was observed to be in a good state of
health without any complaints or signs of her previously diagnosed condition.