Full text appears below.
Or download official US Patent Office image files of this
Tif files (best quality): page
1 page 2
If you have difficulties with TIF file format, we
recommend downloading and installing the AlternaTIFF
plug-in for Windows, Quicktime for MacIntosh, and Plugger for Linux.
UNITED STATES PATENT OFFICE
Patent Number 2,145,869 Patented Feb. 7, 1939
INTRAVENOUS THERAPY FOR THE TREATMENT OF SYPHILIS
Donato Perez Garcia,
No Drawing. Application July 13, 1935.
Serial No. 31,287
2 claims. (Cl. 167-69)
My invention relates to a composition and system for the treatment of neurosyphilis,
and in general for the treatment of syphilis in any one of its stages. The system and
composition are radical in that they make a definite progress in the treatment of the
The system is based on the simultaneous use of certain chemicals and treatments which
to some extent have already been known to be beneficial in the treatment of the disease,
although not in association with each other or in the proportions herein set forth. The
use of these materials in the proportions herein set forth cannot have a fatal toxic
result because of the method I employ for preparing the patient for their reception.
Through my discovery, the use of doses of the materials in the quantity and proportions
herein set forth is made possible, with the consequent beneficial results.
The use of a glucose solution by intravenous injection is beneficial in the treatment
of neurosyphilis or of syphilis in general, but by itself it can have no real value as a
treatment for these diseases. In my system of treatment, I use as a vehicle for the
administration of remedial agents for the treatment of these diseases, a glucose solution
of 30% with chemically pure calcium chloride in the proportions of fifteen cubic
centimeters of glucose solution with about 0.50 gramme of calcium chloride. I use the
foregoing quantity for one intravenous injection.
This compound can be mixed if desired, with arsenical salts of the well known
"Neo-Salvarsan' type, such as "Neo-Arspenemine", "Neo-Diarsenol",
etc. Likewise, the glucose solution may be of 30% and may be injected in quantities of
from ten cubic centimeters up to twenty cubic centimeters. The quantity of calcium
chloride employed and put in the solution of glucose may vary from one-half to one gramme.
The solution may be prepared in the desired strength within the limits above set forth
and put up in ampules of glass or other convenient dose measurements.
The dose in respect to the quantity of calcium chloride varies according to the
sensibility of the patient for calcium. This is determined with the first injection, of
the small amount, subsequent injections containing more according to the results.
In preparing the formula for practical use, I take an ampule of for instance somewhat
more than 15 cubic centimeters capacity, place one gramme, 50 centigrammes of chloride or
gluconate of chemically pure calcium and 4 grammes plus 50 centigrammes of chemically pure
glucose therein. I then seal the ampule in the usual manner with the proper precautions as
to sterilization, such as are customary in the production of ampules of this type.
Approximately 15 cubic centimeters of double distilled water may be added.
To make use of the foregoing solution and substances possible in the quantities
mentioned, without fatal results to the patient being treated, the patient must first be
prepared to be able to withstand the injection, as it is well known that the human body
has a limit of resistance to intravenous injections of this type, beyond which limit the
injection is likely to have fatal results.
I prepare the patient by previously injecting a quantity of insulin in such a way that
this injection may produce on him a hypoglycemic shock. This is for two purposes: to
increase the antitoxin function of the organs such as the liver and kidneys, etc., in
charge of such function, and further to give permeability to the nerve cells and all
others of the human body. As the antitoxic function is increased, larger quantities of
medicamental substances than the body would normally be able to tolerate may be injected.
The most successful way of treating the body for diseases of the type herein mentioned
is to saturate the organism with the medicaments used. Arsenic, mercury and bismuth, as
well as glucose and calcium chloride would he toxic in the large doses required to
saturate the organism of a patient in the ordinary manner of using and applying them by
injection. With this system, they are not toxic, and, therefore, larger quantities than
usual may be applied, either singly or in combination.
Prior to my invention or discovery thereof, hypertonic solutions of glucose have not
been employed for the treatment of syphilis. In my system, the glucose has two effects: it
serves as a vehicle as well as a curative agent in and of itself. It serves as a vehicle
because in it are dissolved the other curative agents mentioned.
The glucose in my formula serves as a curative agent in the sense of curing the state
of hypoglycemia. As the quantity is larger than the one needed to isotonize the blood it
also has a curative effect because, due to being hypertonic, when the blood becomes
hypotonic as a result of the effect of the insulin, the quantity of the cristaloid of the
blood increases in this way in such a manner that due to its high concentration it forces
the other medicaments accompanying it in the same solution, into all the cells of the
system. Thus, glucose in this sense serves two purposes, a chemical and a physical one.
It is to be noted that glucose of the blood is increased at the moment it is necessary
to increase it, and not before, as otherwise a patient left with merely an injection of
insulin might suffer serious consequences.
The compound prepared according to the formula of this invention, besides possessing
its own beneficial properties may be used as an injection in the manner prescribed, that
is to say after preparation of the patient, to dissolve the arsenical salts of the
"Salvarsan" type, which is commonly used for treatment of syphilis. Further, the
present composition, unlike the arsenical salts mentioned, can be used at any time without
fear of its having undergone some decomposition that would render it dangerous as often
happens with the "Salvarsan" type of treatment, the latter having to be used
practically as soon as prepared to be absolutely safe. Also with the use of the solution
of my invention in the system described, larger quantities of arsenical salts may be
safely employed than would ordinarily be possible for the treatment of the patient. That
is, instead of beginning with a dose of 0.15 gramme, there may be used to start 0.30 or
It will thus be seen that I have provided a system for the beneficial treatment of
syphilis and kindred diseases that respond to the same treatment, wherein the patient is
first prepared for the reception of intravenous injection and then as a result of such
preparation is injected with a solution of glucose and calcium chloride or calcium
gluconate in a quantity that would ordinarily otherwise be fatal, but which in my system
is exceedingly beneficial.
What I claim is:
1. As a vehicle for the intravenous
administration of remedial agents of the arsenical type, a composition containing in a 30%
aqueous glucose solution, calcium chloride in the ratio of one-sixth to one-third of the
2. A medicinal composition for intravenous injection comprising 30 to 45 centigrammes
of an arsenical useful in the treatment of syphilis in a vehicle comprising a 30% aqueous
glucose solution containing calcium chloride in the ratio of one-sixth to one-third of the
DONATO PEREZ GARCIA.
[Note: this document was scanned and transcribed by
optical character recognition. Despite careful editing, errors may have occurred.]
(Return to top of page)