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Future Possibilities and Speculations about IPT
by Chris Duffield

Alzheimer's Disease and IPT

        Whatever drugs are developed for treatment of Alzheimer's disease, IPT could very likely deliver them better into the brain.

        If, as some people think, a buildup of heavy metals in the brain is one cause of Alzheimer's disease, IPT could very likely help get them out of there, as it did the heavy metal drugs that Dr. Perez Garcia 1 used to treat neurosyphilis.

        Some new evidence seems to indicate that Alzheimer's is caused by brain reaction to a hidden bacterial infection, possibly by Chlamydia pneumoniae.  If so,  IPT could very well be the best way to deliver antibiotics to the brain and to potentiate them to fight this infection.  

        IPT may also be able to speed the healing process of brain tissue, in part by stimulating the proliferation and differentiation of neural stem cells (J Neurosci Res 59(3):332-341), and by stimulating the myelination  of neurons (Endocrinology 140(7):3063-72).

        There have been many papers published in the last couple of years about possible roles of insulin in preventing or treating Alzheimer's disease (Science 280(5363):517-519).  Insulin improves memory, partly by binding to the high concentration of insulin receptors in the hippocampus.  It stimulates neuronal growth and inhibits the formation of neurofibrillary tangles (brain lesions that characterize Alzheimer's disease).  And Alzheimer's appears to be associated with some sort of insulin resistance in the brain, and unusually high numbers of insulin receptors in the cortex.  A search of Medline for the terms "Alzheimer disease" and "insulin" comes up with 107 references, so there is plenty of research to analyze in understanding this relationship.

        It could be that the IPT protocol, hit on by luck and careful observation by Dr. Perez Garcia 1, may be an ideal method not only for delivering medications for treating Alzheimer's disease, but also for delivering insulin itself into the brain, where it can stimulate healing.

        It is possible that IPT would be of benefit in treating other neurodegenerative diseases such as Parkinson's disease and Huntington's disease.


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