Organ preparation. Perhaps IPT could be used on the living donor
or the deceased donor body
before organ removal, to reduce the injurious effects of ischemia, and to better prepare the organ's tissues for surviving a long
time in preservation solution.
Organ preservation solution. There are several recipes for
making solution to preserve organs for transplantation, and I am told that
insulin is an important ingredient in at least some and perhaps all of them.
Among other things, the insulin may be increasing cell wall permeability, and
helping cells under stress absorb nutrients and eliminate toxins. Could
organs be preserved longer if IPT-like pulses of insulin followed by glucose
were induced in the surrounding fluid?
Organ tolerance. Perhaps IPT could allow use of smaller doses of
immunosuppressive drugs, with reduced toxic side effects. It would also be
interesting to see if IPT, incorporating appropriate medications to modulate
immune response, stop inflammation, and remove toxins, could help stop transplant
rejection reactions (graft-vs-host disease). A big advantage of IPT
appears to be its ability to transport drugs effectively even into inflamed and