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Future Possibilities and Speculations about IPT
by Chris Duffield

Organ preparation.  Perhaps IPT could be used on the living donor or the deceased donor body before organ removal, to reduce the injurious effects of ischemia, and to better prepare the organ's tissues for surviving a long time in preservation solution.

Organ preservation solution.  There are several recipes for making solution to preserve organs for transplantation, and I am told that insulin is an important ingredient in at least some and perhaps all of them.   Among other things, the insulin may be increasing cell wall permeability, and helping cells under stress absorb nutrients and eliminate toxins.  Could organs be preserved longer if IPT-like pulses of insulin followed by glucose were induced in the surrounding fluid?

Organ tolerance.  Perhaps IPT could allow use of smaller doses of immunosuppressive drugs, with reduced toxic side effects.  It would also be interesting to see if IPT, incorporating appropriate medications to modulate immune response, stop inflammation, and remove toxins, could help stop transplant rejection reactions (graft-vs-host disease).   A big advantage of IPT appears to be its ability to transport drugs effectively even into inflamed and necrotic tissues.

 

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